Activated microglia are one of the early hallmarks of Alzheimer’s disease (AD) pathogenesis. Both amyloid beta (Aβ) and tau trigger a cascade of functional changes in neurons, microglia, astrocytes, and oligodendrocytes, which results in neuronal dysfunction, synaptic loss, innate immune system activation, inflammation, and neurodegeneration.
Cytokines play a central role in controlling inflammation and contributing to the balance between immune activation and suppression. Enzo offers hundreds of ultrasensitive, time-saving, and widely cited ELISA kits to measure pro- (IL-1, IL-6, TNF-α, IL-12) and anti-inflammatory factors (IL-4, IL-10) in neurodegenerative diseases.
Pair Enzo’s new plate reader with any of our 250 ELISAs cited in more than 200 publications, including the amyloid precursor protein APP ΔC31 ELISA kit. Learn how Poksay et al. used Enzo’s APP ΔC31 ELISA kit in their study.
|